Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

Prenylated proteins play key roles in several human diseases including cancer, atherosclerosis and Alzheimer’s disease. KRAS4b, which is frequently mutated in pancreatic, colon and lung cancers, is processed by farnesylation, proteolytic cleavage and carboxymethylation at the C-terminus. Plasma memb...

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Publicat a:Sci Rep
Autors principals: Gillette, William K., Esposito, Dominic, Abreu Blanco, Maria, Alexander, Patrick, Bindu, Lakshman, Bittner, Cammi, Chertov, Oleg, Frank, Peter H., Grose, Carissa, Jones, Jane E., Meng, Zhaojing, Perkins, Shelley, Van, Que, Ghirlando, Rodolfo, Fivash, Matthew, Nissley, Dwight V., McCormick, Frank, Holderfield, Matthew, Stephen, Andrew G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629113/
https://ncbi.nlm.nih.gov/pubmed/26522388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15916
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