Chemical derivatization of histones for facilitated analysis by mass spectrometry

Histone post-translational modifications have been recently intensely studied owing to their role in regulating gene expression. Here, we describe protocols for the characterization of histone modifications in both qualitative and semiquantitative manners using chemical derivatization and tandem mas...

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Bibliographic Details
Published in:Nat Protoc
Main Authors: Garcia, Benjamin A, Mollah, Sahana, Ueberheide, Beatrix M, Busby, Scott A, Muratore, Tara L, Shabanowitz, Jeffrey, Hunt, Donald F
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627699/
https://ncbi.nlm.nih.gov/pubmed/17446892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2007.106
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