Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ cell tumor (GCT) cell lines, hormone-sensitive and castration-resistant prostate...

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Publicado en:Oncotarget
Autores principales: Dyshlovoy, Sergey A., Hauschild, Jessica, Amann, Kerstin, Tabakmakher, Ksenia M., Venz, Simone, Walther, Reinhard, Guzii, Alla G., Makarieva, Tatiana N., Shubina, Larisa K., Fedorov, Sergey N., Stonik, Valentin A., Bokemeyer, Carsten, Balabanov, Stefan, Honecker, Friedemann, Amsberg, Gunhild v.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627311/
https://ncbi.nlm.nih.gov/pubmed/26093146
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