Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ cell tumor (GCT) cell lines, hormone-sensitive and castration-resistant prostate...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Dyshlovoy, Sergey A., Hauschild, Jessica, Amann, Kerstin, Tabakmakher, Ksenia M., Venz, Simone, Walther, Reinhard, Guzii, Alla G., Makarieva, Tatiana N., Shubina, Larisa K., Fedorov, Sergey N., Stonik, Valentin A., Bokemeyer, Carsten, Balabanov, Stefan, Honecker, Friedemann, Amsberg, Gunhild v.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627311/
https://ncbi.nlm.nih.gov/pubmed/26093146
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