Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization

Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ cell tumor (GCT) cell lines, hormone-sensitive and castration-resistant prostate...

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Foilsithe in:Oncotarget
Main Authors: Dyshlovoy, Sergey A., Hauschild, Jessica, Amann, Kerstin, Tabakmakher, Ksenia M., Venz, Simone, Walther, Reinhard, Guzii, Alla G., Makarieva, Tatiana N., Shubina, Larisa K., Fedorov, Sergey N., Stonik, Valentin A., Bokemeyer, Carsten, Balabanov, Stefan, Honecker, Friedemann, Amsberg, Gunhild v.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2015
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627311/
https://ncbi.nlm.nih.gov/pubmed/26093146
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