Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death

Chemoresistance in cancer has previously been attributed to gene mutations or deficiency. Caspase mutations or Bax deficiency can lead to resistance to cancer drugs. We recently demonstrated that Bak initiates a caspase/Bax-independent cell death pathway. We show that Plumbagin (PL) (5-hydroxy-2-met...

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Vydáno v:Oncotarget
Hlavní autoři: Wang, Jinjing, Guo, Wenhao, Zhou, Hang, Luo, Na, Nie, Chunlai, Zhao, Xinyu, Yuan, Zhu, Liu, Xinyu, Wei, Yuquan
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627301/
https://ncbi.nlm.nih.gov/pubmed/25980443
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