Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death

Chemoresistance in cancer has previously been attributed to gene mutations or deficiency. Caspase mutations or Bax deficiency can lead to resistance to cancer drugs. We recently demonstrated that Bak initiates a caspase/Bax-independent cell death pathway. We show that Plumbagin (PL) (5-hydroxy-2-met...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Jinjing, Guo, Wenhao, Zhou, Hang, Luo, Na, Nie, Chunlai, Zhao, Xinyu, Yuan, Zhu, Liu, Xinyu, Wei, Yuquan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627301/
https://ncbi.nlm.nih.gov/pubmed/25980443
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