Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

Aberrations in the mTOR (mechanistic target of rapamycin) axis are frequently reported in cancer. Using publicly available tumor genome sequencing data, we identified several point mutations in MTOR and its upstream regulator RHEB (Ras homolog enriched in brain) in patients with clear cell renal cel...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ghosh, Arindam P., Marshall, Christopher B., Coric, Tatjana, Shim, Eun-hee, Kirkman, Richard, Ballestas, Mary E., Ikura, Mitsuhiko, Bjornsti, Mary-Ann, Sudarshan, Sunil
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627224/
https://ncbi.nlm.nih.gov/pubmed/26255626
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