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Hypoxic induction of T‐type Ca(2+) channels in rat cardiac myocytes: role of HIF‐1α and RhoA/ROCK signalling

KEY POINTS: T‐type Ca(2+) channels are expressed in the ventricular myocytes of the fetal and perinatal heart, but are downregulated as development progresses. However, these channels are re‐expressed in adult cardiomyocytes under pathological conditions. Hypoxia induces the upregulation of the T‐ty...

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Détails bibliographiques
Publié dans:J Physiol
Auteurs principaux: González‐Rodríguez, P., Falcón, D., Castro, M. J., Ureña, J., López‐Barneo, J., Castellano, A.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626545/
https://ncbi.nlm.nih.gov/pubmed/26331302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271053
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