Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium

The bis-retinoid N-retinylidene-N-retinylethanolamine (A2E) is one of the major components of lipofuscin, a fluorescent material that accumulates with age in the lysosomes of the retinal pigment epithelium (RPE) of the human eye. Lipofuscin, as well as A2E, exhibit a range of cytotoxic properties, w...

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Detalhes bibliográficos
Publicado no:Photochem Photobiol Sci
Main Authors: Adler, Leopold, Boyer, Nicholas P., Anderson, David M., Spraggins, Jeffrey M., Schey, Kevin L., Hanneken, Anne, Ablonczy, Zsolt, Crouch, Rosalie K., Koutalos, Yiannis
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626405/
https://ncbi.nlm.nih.gov/pubmed/26323192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5pp00156k
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