Lipofuscin and N-Retinylidene-N-Retinylethanolamine (A2E) Accumulate in Retinal Pigment Epithelium in Absence of Light Exposure: THEIR ORIGIN IS 11-cis-RETINAL

The age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) has been associated with the development of retinal diseases, particularly age-related macular degeneration and Stargardt disease. A major component of lipofuscin is the bis-retinoid N-retinylidene-N-retinylethanola...

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Detalhes bibliográficos
Principais autores: Boyer, Nicholas P., Higbee, Daniel, Currin, Mark B., Blakeley, Lorie R., Chen, Chunhe, Ablonczy, Zsolt, Crouch, Rosalie K., Koutalos, Yiannis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381188/
https://ncbi.nlm.nih.gov/pubmed/22570475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329235
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