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Lack of Correlation Between the Spatial Distribution of A2E and Lipofuscin Fluorescence in the Human Retinal Pigment Epithelium

PURPOSE. The accumulation of lipofuscin in the RPE is a hallmark of aging in the eye. The best characterized component of lipofuscin is A2E, a bis-retinoid byproduct of the normal retinoid visual cycle, which exhibits a broad spectrum of cytotoxic effects in vitro. The purpose of our study was to co...

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Detalhes bibliográficos
Main Authors: Ablonczy, Zsolt, Higbee, Daniel, Anderson, David M., Dahrouj, Mohammad, Grey, Angus C., Gutierrez, Danielle, Koutalos, Yiannis, Schey, Kevin L., Hanneken, Anne, Crouch, Rosalie K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747789/
https://ncbi.nlm.nih.gov/pubmed/23847313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12250
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