Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas

Stargardt disease is a juvenile onset retinal degeneration, associated with elevated levels of lipofuscin and its bis-retinoid components, such as N-retinylidene-N-retinylethanolamine (A2E). However, the pathogenesis of Stargardt is still poorly understood and targeted treatments are not available....

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Publicado no:Sci Rep
Main Authors: Anderson, David M. G., Ablonczy, Zsolt, Koutalos, Yiannis, Hanneken, Anne M., Spraggins, Jeffrey M., Calcutt, M. Wade, Crouch, Rosalie K., Caprioli, Richard M., Schey, Kevin L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725462/
https://ncbi.nlm.nih.gov/pubmed/29229934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17402-1
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