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Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells.

The only known component of the infectious prion is a posttranslationally modified protein known as the scrapie isoform of the prion protein, PrPSc. Upon limited proteolysis, a protease-resistant fragment designated PrP 27-30 is formed. Using in vitro mutagenesis, we examined the role of the N and C...

詳細記述

保存先:
書誌詳細
主要な著者: Rogers, M, Yehiely, F, Scott, M, Prusiner, S B
フォーマット: Artigo
言語:Inglês
出版事項: 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC46263/
https://ncbi.nlm.nih.gov/pubmed/8475059
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