Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells.
The only known component of the infectious prion is a posttranslationally modified protein known as the scrapie isoform of the prion protein, PrPSc. Upon limited proteolysis, a protease-resistant fragment designated PrP 27-30 is formed. Using in vitro mutagenesis, we examined the role of the N and C...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46263/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8475059/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3182 |
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