Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.

Thalassemias are hereditary anemias caused by mutations that disturb the normal 1:1 balance of alpha- and beta-globin chains that form hemoglobin. We have disrupted the major adult beta-globin gene (b1) in mouse embryonic stem cells by using homologous recombination to insert selectable sequences in...

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Bibliographic Details
Main Authors: Shehee, W R, Oliver, P, Smithies, O
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC46262/
https://ncbi.nlm.nih.gov/pubmed/8475058
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