Correction of a human beta S-globin gene by gene targeting.

As a step toward using gene targeting for gene therapy, we have corrected a human beta S-globin gene to the normal beta A allele by homologous recombination in the mouse-human hybrid cell line BSM. BSM is derived from a mouse erythroleukemia cell line and carries a single human chromosome 11 with th...

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Main Authors: Shesely, E G, Kim, H S, Shehee, W R, Papayannopoulou, T, Smithies, O, Popovich, B W
Format: Artigo
Sprog:Inglês
Udgivet: 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC51645/
https://ncbi.nlm.nih.gov/pubmed/2034673
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