Correction of a human beta S-globin gene by gene targeting.

As a step toward using gene targeting for gene therapy, we have corrected a human beta S-globin gene to the normal beta A allele by homologous recombination in the mouse-human hybrid cell line BSM. BSM is derived from a mouse erythroleukemia cell line and carries a single human chromosome 11 with th...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Proc Natl Acad Sci U S A
Päätekijät:	Shesely, E G, Kim, H S, Shehee, W R, Papayannopoulou, T, Smithies, O, Popovich, B W
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	National Academy of Sciences 1991
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51645/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2034673/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.10.4294
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