Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
Globin genes are subject to tissue-specific and developmental stage-specific regulation. A switch from human fetal (gamma)-to adult (beta)-globin expression occurs within erythroid precursor cells of the adult lineage. Previously we and others showed by targeted gene disruption that the zinc finger...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37979/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8901569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.22.12267 |
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