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Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.

Globin genes are subject to tissue-specific and developmental stage-specific regulation. A switch from human fetal (gamma)-to adult (beta)-globin expression occurs within erythroid precursor cells of the adult lineage. Previously we and others showed by targeted gene disruption that the zinc finger...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Perkins, A C, Gaensler, K M, Orkin, S H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC37979/
https://ncbi.nlm.nih.gov/pubmed/8901569
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