Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.
Thalassemias are hereditary anemias caused by mutations that disturb the normal 1:1 balance of alpha- and beta-globin chains that form hemoglobin. We have disrupted the major adult beta-globin gene (b1) in mouse embryonic stem cells by using homologous recombination to insert selectable sequences in...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1993
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46262/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8475058/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3177 |
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