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Robust and efficient parameter estimation in dynamic models of biological systems

BACKGROUND: Dynamic modelling provides a systematic framework to understand function in biological systems. Parameter estimation in nonlinear dynamic models remains a very challenging inverse problem due to its nonconvexity and ill-conditioning. Associated issues like overfitting and local solutions...

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Bibliografske podrobnosti
izdano v:BMC Syst Biol
Main Authors: Gábor, Attila, Banga, Julio R.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625902/
https://ncbi.nlm.nih.gov/pubmed/26515482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-015-0219-2
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