Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination

Ischemia-reperfusion injury (IRI) is the leading cause of ARF. A pathophysiologic role of the coagulation system in renal IRI has been established, but the functional relevance of thrombomodulin (TM)-dependent activated protein C (aPC) generation and the intracellular targets of aPC remain undefined...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Dong, Wei, Wang, Hongjie, Shahzad, Khurrum, Bock, Fabian, Al-Dabet, Moh'd Mohanad, Ranjan, Satish, Wolter, Juliane, Kohli, Shrey, Hoffmann, Juliane, Dhople, Vishnu Mukund, Zhu, Cheng, Lindquist, Jonathan A., Esmon, Charles T., Gröne, Elisabeth, Gröne, Herman-Josef, Madhusudhan, Thati, Mertens, Peter R., Schlüter, Dirk, Isermann, Berend
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2015
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625674/
https://ncbi.nlm.nih.gov/pubmed/26015455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014080846
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