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Lack of Intraclonal Diversification in Ig Heavy and Light Chain V Region Genes Expressed by CD5(+)IgM(+) Chronic Lymphocytic Leukemia B Cells: A Multiple Time Point Analysis()

To analyze the modalities of clonal expansion of chronic lymphocytic leukemia (CLL) cells, we sequenced at multiple time points the V(D)J genes expressed by CD5(+)IgM(+)CLL B cells in three patients. All three V(D)J gene sequences were found to be point mutated. The mutation frequency in the Ig V(H)...

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Publicado en:J Immunol
Main Authors: Schettino, Edward W., Cerutti, Andrea, Chiorazzi, Nicholas, Casali, Paolo
Formato: Artigo
Idioma:Inglês
Publicado: 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625536/
https://ncbi.nlm.nih.gov/pubmed/9551917
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