Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin V(H)DJ(H) Gene Diversification

Chronic lymphocytic leukemia (CLL) arises from the clonal expansion of a CD5(+) B lymphocyte that is thought not to undergo intraclonal diversification. Using V(H)DJ(H) cDNA single strand conformation polymorphism analyses, we detected intraclonal mobility variants in 11 of 18 CLL cases. cDNA sequen...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Gurrieri, Carmela, McGuire, Peter, Zan, Hong, Yan, Xiao-Jie, Cerutti, Andrea, Albesiano, Emilia, Allen, Steven L., Vinciguerra, Vincent, Rai, Kanti R., Ferrarini, Manlio, Casali, Paolo, Chiorazzi, Nicholas
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2002
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194006/
https://ncbi.nlm.nih.gov/pubmed/12208878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011693
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky