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Lack of Intraclonal Diversification in Ig Heavy and Light Chain V Region Genes Expressed by CD5(+)IgM(+) Chronic Lymphocytic Leukemia B Cells: A Multiple Time Point Analysis()
To analyze the modalities of clonal expansion of chronic lymphocytic leukemia (CLL) cells, we sequenced at multiple time points the V(D)J genes expressed by CD5(+)IgM(+)CLL B cells in three patients. All three V(D)J gene sequences were found to be point mutated. The mutation frequency in the Ig V(H)...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4625536/ https://ncbi.nlm.nih.gov/pubmed/9551917 |
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