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IL-4 rescues surface IgM expression in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) cells express poor levels of surface immunoglobulin (sIg), and many are minimally activated or anergic in response to B-cell receptor (BCR) crosslinking in vitro. Paradoxically, CLL cells in patients are highly activated through BCR signaling and expand in prolifer...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Guo, Benchang, Zhang, Lu, Chiorazzi, Nicholas, Rothstein, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965907/
https://ncbi.nlm.nih.gov/pubmed/27226435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-682997
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