Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressive neuronal dysfunction, loss of synaptic spine densit...

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Vydáno v:Sci Rep
Hlavní autoři: Barucker, Christian, Bittner, Heiko J., Chang, Philip K.-Y., Cameron, Scott, Hancock, Mark A., Liebsch, Filip, Hossain, Shireen, Harmeier, Anja, Shaw, Hunter, Charron, François M., Gensler, Manuel, Dembny, Paul, Zhuang, Wei, Schmitz, Dietmar, Rabe, Jürgen P., Rao, Yong, Lurz, Rudi, Hildebrand, Peter W., McKinney, R. Anne, Multhaup, Gerhard
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625140/
https://ncbi.nlm.nih.gov/pubmed/26510576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15410
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