Targeting Integrin-Dependent Adhesion and Signaling with 3-Arylquinoline and 3-Aryl-2-Quinolone Derivatives: A new Class of Integrin Antagonists

We previously reported the anti-migratory function of 3-aryl-2-quinolone derivatives, chemically close to flavonoids (Joseph et al., 2002). Herein we show that 3-arylquinoline or 3-aryl-2-quinolone derivatives disrupt cell adhesion in a dose dependent and reversible manner yet antagonized by artific...

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Bibliographic Details
Published in:PLoS One
Main Authors: Fiorucci, Sandrine, Lin, Xiaochen, Sadoul, Karin, Fournet, Guy, Bouvard, Daniel, Vinogradova, Olga, Joseph, Benoît, Block, Marc R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624933/
https://ncbi.nlm.nih.gov/pubmed/26509443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141205
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