Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids

[Image: see text] We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other steroid nuclear hormone receptor...

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Главные авторы: Richardson, Timothy I., Clarke, Christian A., Yu, Kuo-Long, Yee, Ying K., Bleisch, Thomas J., Lopez, Jose E., Jones, Scott A., Hughes, Norman E., Muehl, Brian S., Lugar, Charles W., Moore, Terry L., Shetler, Pamela K., Zink, Richard W., Osborne, John J., Montrose-Rafizadeh, Chahrzad, Patel, Nita, Geiser, Andrew G., Galvin, Rachelle J. Sells, Dodge, Jeffrey A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2010
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017981/
https://ncbi.nlm.nih.gov/pubmed/24900294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100220b
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