Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids

[Image: see text] We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other steroid nuclear hormone receptor...

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Main Authors: Richardson, Timothy I., Clarke, Christian A., Yu, Kuo-Long, Yee, Ying K., Bleisch, Thomas J., Lopez, Jose E., Jones, Scott A., Hughes, Norman E., Muehl, Brian S., Lugar, Charles W., Moore, Terry L., Shetler, Pamela K., Zink, Richard W., Osborne, John J., Montrose-Rafizadeh, Chahrzad, Patel, Nita, Geiser, Andrew G., Galvin, Rachelle J. Sells, Dodge, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017981/
https://ncbi.nlm.nih.gov/pubmed/24900294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100220b
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