Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110

BACKGROUND: Bispecific T cell engager (BiTE(®)) are single-chain bispecific antibody constructs with dual specificity for CD3 on T cells and a surface antigen on target cells. They can elicit a polyclonal cytotoxic T cell response that is not restricted by T cell receptor (TCR) specificity, and surf...

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Udgivet i:PLoS One
Main Authors: Deisting, Wibke, Raum, Tobias, Kufer, Peter, Baeuerle, Patrick A., Münz, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624873/
https://ncbi.nlm.nih.gov/pubmed/26510188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141669
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