Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110

Ectodomains of target antigens for antibody-based therapies can be shed from the target cell surface and found in sera of patients. Shed ectodomains of therapeutic targets not only pose the risk of sequestering therapeutic antibodies but, in a multimeric form, of triggering T cell activation by bisp...

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Autori principali: Petsch, Silke, Gires, Olivier, Rüttinger, Dominik, Denzel, Sabine, Lippold, Sandra, Baeuerle, Patrick A, Wolf, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038009/
https://ncbi.nlm.nih.gov/pubmed/21107020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.1.14193
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