Highly Efficient Elimination of Colorectal Tumor-Initiating Cells by an EpCAM/CD3-Bispecific Antibody Engaging Human T Cells

With their resistance to genotoxic and anti-proliferative drugs and potential to grow tumors and metastases from very few cells, cancer stem or tumor-initiating cells (TICs) are a severe limitation for the treatment of cancer by conventional therapies. Here, we explored whether human T cells that ar...

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Bibliographische Detailangaben
Hauptverfasser: Herrmann, Ines, Baeuerle, Patrick A., Friedrich, Matthias, Murr, Alexander, Filusch, Susanne, Rüttinger, Dominik, Majdoub, Mariam W., Sharma, Sherven, Kufer, Peter, Raum, Tobias, Münz, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956687/
https://ncbi.nlm.nih.gov/pubmed/20976159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013474
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