E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis

BACKGROUND: Missense mutation of VHL gene is frequently detected in type 2 VHL diseases and linked to a wide range of pVHL functions and stability. Certain mutant pVHLs retain ability to regulate HIFs but lose their function by instability. In this case, regulating of degradation of mutant pVHLs, ca...

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Pubblicato in:BMC Cancer
Autori principali: Park, Kyeong-Su, Kim, Ju Hee, Shin, Hee Won, Chung, Kyung-Sook, Im, Dong-Soo, Lim, Jung Hwa, Jung, Cho-Rok
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624580/
https://ncbi.nlm.nih.gov/pubmed/26503325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1786-8
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