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Immunoglobulin Somatic Hypermutation: Double-Strand DNA Breaks, AID and Error-Prone DNA Repair
Somatic hypermutation (SHM) is critical for antibody affinity maturation and the generation of memory B cells. Somatic mutations consist mainly of single nucleotide changes with rare insertions and deletions. Such changes would be introduced during error-prone repair of lesions involving single-stra...
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| Veröffentlicht in: | J Clin Immunol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624321/ https://ncbi.nlm.nih.gov/pubmed/12959216 |
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