Immunoglobulin Somatic Hypermutation: Double-Strand DNA Breaks, AID and Error-Prone DNA Repair

Somatic hypermutation (SHM) is critical for antibody affinity maturation and the generation of memory B cells. Somatic mutations consist mainly of single nucleotide changes with rare insertions and deletions. Such changes would be introduced during error-prone repair of lesions involving single-stra...

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Udgivet i:J Clin Immunol
Main Authors: WU, XIAOPING, FENG, JUNLI, KOMORI, ATSUMASA, KIM, EDMUND C., ZAN, HONG, CASALI, PAOLO
Format: Artigo
Sprog:Inglês
Udgivet: 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624321/
https://ncbi.nlm.nih.gov/pubmed/12959216
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