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Antigenic sites on the H(N) domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin
Botulinum neurotoxins (BoNTs) are the most toxic substances known. BoNT intoxicates cells in a highly programmed fashion initiated by binding to the cell surface, internalization and enzymatic cleavage of substrate, thus, inhibiting synaptic exocytosis. Over the past two decades, immunological signi...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623786/ https://ncbi.nlm.nih.gov/pubmed/26508475 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15776 |
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