Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains

Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and...

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Detalhes bibliográficos
Main Authors: Toth, Stephen, Brueggmann, Ernst E., Oyler, George A., Smith, Leonard A., Hines, Harry B., Ahmed, S. Ashraf
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2012
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366388/
https://ncbi.nlm.nih.gov/pubmed/22675300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00102
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