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Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains
Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Research Foundation
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366388/ https://ncbi.nlm.nih.gov/pubmed/22675300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00102 |
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