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High-Affinity, Protective Antibodies to the Binding Domain of Botulinum Neurotoxin Type A

Monoclonal antibodies (MAbs) were prepared against the putative binding domain of botulinum neurotoxin A (BoNT/A), a nontoxic 50-kDa fragment. Initially, all fusion products were screened against the holotoxin BoNT/A and against the binding fragment, BoNT/A H(C). Eleven neutralizing hybridomas were...

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Udgivet i:Infect Immun
Principais autores: Pless, Dorothy D., Torres, Edna R., Reinke, Emily K., Bavari, Sina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97921/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11119555/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.1.570-574.2001
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