Phage-Displayed T-Cell Epitope Grafted into Immunoglobulin Heavy-Chain Complementarity-Determining Regions: an Effective Vaccine Design Tested in Murine Cysticercosis

A new type of immunogenic molecule was engineered by replacing all three complementarity-determining-region (CDR) loops of the human immunoglobulin (Ig) heavy-chain variable (V(H)) domain with the Taenia crassiceps epitope PT1 (PPPVDYLYQT) and by displaying this construct on the surfaces of M13 bact...

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Bibliographische Detailangaben
Hauptverfasser: Manoutcharian, Karen, Terrazas, Luis Ignacio, Gevorkian, Goar, Acero, Gonzalo, Petrossian, Pavel, Rodriguez, Miriam, Govezensky, Tzipe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC96807/
https://ncbi.nlm.nih.gov/pubmed/10456929
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