Phage-Displayed T-Cell Epitope Grafted into Immunoglobulin Heavy-Chain Complementarity-Determining Regions: an Effective Vaccine Design Tested in Murine Cysticercosis

A new type of immunogenic molecule was engineered by replacing all three complementarity-determining-region (CDR) loops of the human immunoglobulin (Ig) heavy-chain variable (V(H)) domain with the Taenia crassiceps epitope PT1 (PPPVDYLYQT) and by displaying this construct on the surfaces of M13 bact...

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Опубликовано в::	Infect Immun
Главные авторы:	Manoutcharian, Karen, Terrazas, Luis Ignacio, Gevorkian, Goar, Acero, Gonzalo, Petrossian, Pavel, Rodriguez, Miriam, Govezensky, Tzipe
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1999
Предметы:	Microbial Immunity and Vaccines
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96807/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10456929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.9.4764-4770.1999
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