Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody

SM03, a chimeric antibody that targets the B-cell restricted antigen CD22, is currently being clinically evaluated for the treatment of lymphomas and other autoimmune diseases in China. SM03 binding to surface CD22 leads to rapid internalization, making the development of an appropriate cell-based b...

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Veröffentlicht in:MAbs
Hauptverfasser: Leung, Shui-on, Gao, Kai, Wang, Guang Yu, Cheung, Benny Ka-wa, Lee, Kwan-yeung, Zhao, Qi, Cheung, Wing-Tai, Wang, Jun Zhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2014
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Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623522/
https://ncbi.nlm.nih.gov/pubmed/25427174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.985519
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