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ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations
The increased risk of developing Alzheimer’s disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 an...
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| Опубликовано в: : | PLoS Comput Biol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623519/ https://ncbi.nlm.nih.gov/pubmed/26506597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004359 |
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