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Molecular Mechanisms of the R61T Mutation in Apolipoprotein E4: A Dynamic Rescue
The apolipoprotein E4 (ApoE4) gene is the strongest genetic risk factor for Alzheimer’s disease (AD). With respect to the other common isoforms of this protein (ApoE2 and ApoE3), ApoE4 is characterized by lower stability that underlies the formation of a stable interaction between the protein’s N- a...
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| Vydáno v: | Biophys J |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700245/ https://ncbi.nlm.nih.gov/pubmed/28916386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.026 |
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