MOLECULAR MECHANISMS OF FUNCTIONAL RESCUE MEDIATED BY P53 TUMOR SUPPRESSOR MUTATIONS

We have utilized both molecular dynamics simulations and solution biophysical measurements to investigate the rescue mechanism of mutation N235K, which plays a key role in the recently identified global suppressor motif of K235/Y239/R240 in the human p53 DNA-binding domain (DBD). Previous genetic an...

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Detalhes bibliográficos
Main Authors: Tan, Yu-Hong, Chen, Y. Morris, Ye, Xiang, Lu, Qiang, Tretyachenko-Ladokhina, Vira, Yang, Wei, Senear, Donald F., Luo, Ray
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794655/
https://ncbi.nlm.nih.gov/pubmed/19748724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2009.08.008
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