Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

Fc effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP) are crucial to the efficacy of many antibody therapeutics. In addition to IgG, antibodies of the IgA isotype can also promote cell killing through engagement of...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Borrok, M Jack, Luheshi, Nadia M, Beyaz, Nurten, Davies, Gareth C, Legg, James W, Wu, Herren, Dall'Acqua, William F, Tsui, Ping
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623516/
https://ncbi.nlm.nih.gov/pubmed/25970007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1047570
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