miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively

miRNAs typically downregulate the expression of target genes by binding to their 3′UTR, and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that miR-346 and miR-138 competitively bind to a common region in the 3′UTR of hTERT mRNA and have opposite effects on the expression an...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Song, Ge, Wang, Renjie, Guo, Junfei, Liu, Xuyuan, Wang, Fang, Qi, Ying, Wan, Haiying, Liu, Min, Li, Xin, Tang, Hua
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623477/
https://ncbi.nlm.nih.gov/pubmed/26507454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15793
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