miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively

miRNAs typically downregulate the expression of target genes by binding to their 3′UTR, and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that miR-346 and miR-138 competitively bind to a common region in the 3′UTR of hTERT mRNA and have opposite effects on the expression an...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Song, Ge, Wang, Renjie, Guo, Junfei, Liu, Xuyuan, Wang, Fang, Qi, Ying, Wan, Haiying, Liu, Min, Li, Xin, Tang, Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623477/
https://ncbi.nlm.nih.gov/pubmed/26507454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15793
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky