miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively

miRNAs typically downregulate the expression of target genes by binding to their 3′UTR, and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that miR-346 and miR-138 competitively bind to a common region in the 3′UTR of hTERT mRNA and have opposite effects on the expression an...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Song, Ge, Wang, Renjie, Guo, Junfei, Liu, Xuyuan, Wang, Fang, Qi, Ying, Wan, Haiying, Liu, Min, Li, Xin, Tang, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623477/
https://ncbi.nlm.nih.gov/pubmed/26507454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15793
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