Altered promoter nucleosome positioning is an early event in gene silencing

Gene silencing in cancer frequently involves hypermethylation and dense nucleosome occupancy across promoter regions. How a promoter transitions to this silent state is unclear. Using colorectal adenomas, we investigated nucleosome positioning, DNA methylation, and gene expression in the early stage...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Hesson, Luke B, Sloane, Mathew A, Wong, Jason WH, Nunez, Andrea C, Srivastava, Sameer, Ng, Benedict, Hawkins, Nicholas J, Bourke, Michael J, Ward, Robyn L
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622968/
https://ncbi.nlm.nih.gov/pubmed/25437056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.970077
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