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Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure
Hypomethylating agents reactivate tumor suppressor genes that are epigenetically silenced in cancer. Inevitably these genes are resilenced, leading to drug resistance. Using the MLH1 tumor suppressor gene as a model, we showed that decitabine-induced re-expression was dependent upon demethylation an...
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| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3723495/ https://ncbi.nlm.nih.gov/pubmed/23935509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003636 |
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