Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure

Hypomethylating agents reactivate tumor suppressor genes that are epigenetically silenced in cancer. Inevitably these genes are resilenced, leading to drug resistance. Using the MLH1 tumor suppressor gene as a model, we showed that decitabine-induced re-expression was dependent upon demethylation an...

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Main Authors: Hesson, Luke B., Patil, Vibha, Sloane, Mathew A., Nunez, Andrea C., Liu, Jia, Pimanda, John E., Ward, Robyn L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723495/
https://ncbi.nlm.nih.gov/pubmed/23935509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003636
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