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Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients

BACKGROUND: Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome that can be caused by the autosomal dominant inheritance of splice site mutations...

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Publicat a:Clin Epigenetics
Autors principals: Sloane, Mathew A, Hesson, Luke B, Nunez, Andrea C, Thompson, Bryony A, Ward, Robyn L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272815/
https://ncbi.nlm.nih.gov/pubmed/25530820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-014-0032-6
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