Insights into the molecular basis of a bispecific antibody's target selectivity

Bispecific antibodies constitute a valuable class of therapeutics owing to their ability to bind 2 distinct targets. Dual targeting is thought to enhance biological efficacy, limit escape mechanisms, and increase target selectivity via a strong avidity effect mediated by concurrent binding to both a...

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Vydáno v:MAbs
Hlavní autoři: Mazor, Yariv, Hansen, Anna, Yang, Chunning, Chowdhury, Partha S, Wang, Jihong, Stephens, Geoffrey, Wu, Herren, Dall’Acqua, William F
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622944/
https://ncbi.nlm.nih.gov/pubmed/25730144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1022695
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